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    Hospital Pediatrics
    November 2014, VOLUME 4 / ISSUE 6
    Brief Reports

    Utilization of Viral Molecular Diagnostics Among Children Hospitalized With Community Acquired Pneumonia

    Grant S. Schulert, Paul D. Hain, Derek J. Williams
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    Abstract

    Objective: To examine whether results of a polymerase chain reaction–based respiratory viral panel (RVP) are associated with changes in antibiotic use or differential clinical outcomes among children hospitalized with pneumonia.

    Methods: We retrospectively identified otherwise healthy children hospitalized over a 3-year period at a single institution with community-acquired pneumonia who had an RVP performed within 24 hours of admission. We examined associations between RVP results and clinical outcomes as well as management decisions including initiation and duration of intravenous antibiotics.

    Results: Among 202 children, a positive RVP (n = 127, 63%) was associated with a more complicated clinical course, although this was due largely to more severe disease seen in younger children and those with respiratory syncytial virus (n = 38, 30% of positive detections). Detection of a virus did not influence antibiotic therapy. Included children were younger and had more severe illness than children hospitalized with pneumonia at the same institution without an RVP obtained.

    Conclusions: In our study, only respiratory syncytial virus was associated with a more severe clinical course compared with RVP-negative children. Regardless of the virus detected, RVP positivity did not influence antibiotic usage. However, RVP use focused primarily on children with severe pneumonia. Whether similar testing influences management decisions among children with less severe illness deserves further study.

    • molecular diagnostics
    • pneumonia
    • length of stay
    • pediatric
    • outcomes
    • RSV
  • Abbreviations:
    IQR
    interquartile range
    LOS
    length of stay
    RSV
    respiratory syncytial virus
    RVP
    respiratory viral panel
    • Copyright © 2014 by the American Academy of Pediatrics
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    Utilization of Viral Molecular Diagnostics Among Children Hospitalized With Community Acquired Pneumonia
    Grant S. Schulert, Paul D. Hain, Derek J. Williams
    Hospital Pediatrics Nov 2014, 4 (6) 372-376; DOI: 10.1542/hpeds.2014-0018

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    Utilization of Viral Molecular Diagnostics Among Children Hospitalized With Community Acquired Pneumonia
    Grant S. Schulert, Paul D. Hain, Derek J. Williams
    Hospital Pediatrics Nov 2014, 4 (6) 372-376; DOI: 10.1542/hpeds.2014-0018
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    Subjects

    • Pulmonology
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