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Urinary tract infections (UTIs) occur in ∼7% of febrile infants in the first 2 months of life.1 The American Academy of Pediatrics clinical practice guideline for the management of UTIs includes infants between 2 and 24 months of age, but does not provide guidance for infants <2 months.2 This has resulted in significant variability in duration of parenteral therapy in young infants with UTIs, although the factors that drive this variation are less clear.3
In this issue of Hospital Pediatrics, authors of two retrospective studies evaluate patterns in parenteral therapy use for UTI treatment in infants during the first 2 months of life. Marsh et al4 studied 112 infants ≤28 days of age hospitalized for UTI without bacteremia at 2 academic centers. The median duration of parenteral therapy was 49 …
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