Skip to main content

Advertising Disclaimer »

Main menu

  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors/Reviewers
    • Submit Manuscript
    • Author Guidelines
    • Reviewer Guidelines
    • Editorial Policies
    • Open Access
  • Content
    • Current Issue
    • Online First
    • Archive
    • Topic/Program Collections
    • Blog
  • Subscribe
  • Alerts
  • Careers
  • Other Publications
    • American Academy of Pediatrics

User menu

  • Log in
  • My Cart

Search

  • Advanced search
American Academy of Pediatrics

AAP Gateway

Advanced Search

AAP Logo

  • Log in
  • My Cart
  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors/Reviewers
    • Submit Manuscript
    • Author Guidelines
    • Reviewer Guidelines
    • Editorial Policies
    • Open Access
  • Content
    • Current Issue
    • Online First
    • Archive
    • Topic/Program Collections
    • Blog
  • Subscribe
  • Alerts
  • Careers
American Academy of Pediatrics
Research Articles

La Crosse Viral Infection in Hospitalized Pediatric Patients in Western North Carolina

Ansley Miller, Rebecca Carchman, Rachel Long and Sheri A. Denslow
Hospital Pediatrics October 2012, 2 (4) 235-242; DOI: https://doi.org/10.1542/hpeds.2012-0022
Ansley Miller
1Department of Pediatrics, Mission Hospital, Asheville, North Carolina
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rebecca Carchman
1Department of Pediatrics, Mission Hospital, Asheville, North Carolina
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rachel Long
2Public Health Epidemiology, Infection Prevention, Mission Hospital, Asheville, North Carolina
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sheri A. Denslow
2Public Health Epidemiology, Infection Prevention, Mission Hospital, Asheville, North Carolina
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Comments
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Download PDF

Abstract

Objective: La Crosse infection, caused by a rare mosquito-transmitted virus, is endemic in Western North Carolina. Given the large number of cases at our institution, our goal was to describe the presentation, management, and clinical course for pediatric patients with this disease.

Methods: We retrospectively reviewed medical records from pediatric patients with antibody-confirmed La Crosse infection admitted to Mission Hospital July 2004 through August 2009. Demographics, clinical characteristics, management methods, length of hospital stay, and complications were analyzed. Regression analysis was used to assess relationships between presentation and clinical course.

Results: Forty-seven pediatric patients were identified with antibody-confirmed La Crosse infection. Seventy percent were male, and the median age was 8 years. Admission signs and symptoms included fever (43%), headache (94%), vomiting (78%), altered mental status (58%), and seizures (61%). All patients had pleocytosis on cerebrospinal fluid studies (range 10–1063 cells/mm3). Median length of stay was 5 days. Seizure at admission was associated with an increased length of stay (2.4 additional days, 95% confidence interval 0.7–4.1). Eighteen patients (38%) received intensive care, 7 (19%) received parenteral or enteral (via nasogastric tube) nutrition, and 4 (9%) received mechanical ventilation. No statistically significant associations between presenting signs and symptoms and complications were found. Treatments included antibiotics (87%), antiviral medication (55%), seizure prophylaxis (47%), and isotonic fluids (98%).

Conclusions: Our data reflect few indicators to predict clinical course during hospital stay. Management strategies should include attention to development of seizure activity and preventive measures for syndrome of inappropriate antidiuretic hormone.

  • La Crosse viral infection
  • arbovirus
  • meningitis
  • encephalitis
  • treatment
  • Abbreviations:
    CDC
    Centers for Disease Control and Prevention
    CSF
    cerebrospinal fluid
    CT
    computed tomography
    LOS
    length of stay
    PRNT
    plaque reduction neutralization testing
    SIADH
    syndrome of inappropriate antidiuretic hormone
    • Copyright © 2012 by the American Academy of Pediatrics
    View Full Text

    Individual Login

    Log in
    You will be redirected to aap.org to login or to create your account.

    Institutional Login

    via Institution

    You may be able to gain access using your login credentials for your institution. Contact your librarian or administrator if you do not have a username and password.

    Log in through your institution

    If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.

    Purchase access

    You may purchase access to this article. This will require you to create an account if you don't already have one.

    Offer Reprints

    PreviousNext
    Back to top

    Advertising Disclaimer »

    In this issue

    Hospital Pediatrics: 2 (4)
    Hospital Pediatrics
    Vol. 2, Issue 4
    1 Oct 2012
    • Table of Contents
    • Table of Contents (PDF)
    • Index by author
    View this article with LENS
    PreviousNext
    Email Article

    Thank you for your interest in spreading the word on American Academy of Pediatrics.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    La Crosse Viral Infection in Hospitalized Pediatric Patients in Western North Carolina
    (Your Name) has sent you a message from American Academy of Pediatrics
    (Your Name) thought you would like to see the American Academy of Pediatrics web site.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Request Permissions
    Article Alerts
    Log in
    You will be redirected to aap.org to login or to create your account.
    Or Sign In to Email Alerts with your Email Address
    Citation Tools
    La Crosse Viral Infection in Hospitalized Pediatric Patients in Western North Carolina
    Ansley Miller, Rebecca Carchman, Rachel Long, Sheri A. Denslow
    Hospital Pediatrics Oct 2012, 2 (4) 235-242; DOI: 10.1542/hpeds.2012-0022

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Share
    La Crosse Viral Infection in Hospitalized Pediatric Patients in Western North Carolina
    Ansley Miller, Rebecca Carchman, Rachel Long, Sheri A. Denslow
    Hospital Pediatrics Oct 2012, 2 (4) 235-242; DOI: 10.1542/hpeds.2012-0022
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
    Print
    Download PDF
    Insight Alerts
    • Table of Contents

    Jump to section

    • Article
      • Abstract
      • Methods
      • Results
      • Discussion
      • Footnotes
      • References
    • Figures & Data
    • Info & Metrics
    • Comments

    Related Articles

    • No related articles found.
    • PubMed
    • Google Scholar

    Cited By...

    • No citing articles found.
    • Google Scholar

    More in this TOC Section

    • Nurse/Resident Reciprocal Shadowing to Improve Interprofessional Communication
    • Implementation of a Multidisciplinary Debriefing Process for Pediatric Ward Deterioration Events
    • A Multidisciplinary Quality Improvement Initiative to Facilitate Penicillin Allergy Delabeling Among Hospitalized Pediatric Patients
    Show more Research Articles

    Similar Articles

    Subjects

    • Infectious Disease
      • Infectious Disease
      • Epidemiology
    • Journal Info
    • Editorial Board
    • Editorial Policies
    • Overview
    • Licensing Information
    • Authors/Reviewers
    • Author Guidelines
    • Reviewer Guidelines
    • Submit My Manuscript
    • Open Access
    • Librarians
    • Institutional Subscriptions
    • Usage Stats
    • Support
    • Subscribe
    • Contact Us
    • Resources
    • Media Kit
    • About
    • International Access
    • Terms of Use
    • Privacy Statement
    • FAQ
    • RSS Feeds
    • shopAAP
    • AAP.org
    • Follow American Academy of Pediatrics on Instagram
    • Visit American Academy of Pediatrics on Facebook
    • Follow American Academy of Pediatrics on Twitter
    • Follow American Academy of Pediatrics on Youtube
    American Academy of Pediatrics

    © 2021 American Academy of Pediatrics