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American Academy of Pediatrics
Research Articles

Vitamin D in Pediatric Inpatients With Respiratory Illnesses

Sabah Iqbal, Edward V. Mosenkis, Pankaj Jain, Andrew Wiles, Jennifer Lerner, Angela S. Benton, James M. Chamberlain, Robert J. Freishtat and Stephen J. Teach
Hospital Pediatrics October 2013, 3 (4) 371-376; DOI: https://doi.org/10.1542/hpeds.2013-0001
Sabah Iqbal
1Division of Emergency Medicine, and
2Departments of Pediatrics and Emergency Medicine, and
3Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia
4Center for Genetic Medicine Research, Children’s National Medical Center, Washington, District of Columbia
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Edward V. Mosenkis
4Center for Genetic Medicine Research, Children’s National Medical Center, Washington, District of Columbia
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Pankaj Jain
4Center for Genetic Medicine Research, Children’s National Medical Center, Washington, District of Columbia
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Andrew Wiles
4Center for Genetic Medicine Research, Children’s National Medical Center, Washington, District of Columbia
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Jennifer Lerner
4Center for Genetic Medicine Research, Children’s National Medical Center, Washington, District of Columbia
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Angela S. Benton
4Center for Genetic Medicine Research, Children’s National Medical Center, Washington, District of Columbia
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James M. Chamberlain
1Division of Emergency Medicine, and
2Departments of Pediatrics and Emergency Medicine, and
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Robert J. Freishtat
1Division of Emergency Medicine, and
2Departments of Pediatrics and Emergency Medicine, and
3Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia
4Center for Genetic Medicine Research, Children’s National Medical Center, Washington, District of Columbia
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Stephen J. Teach
1Division of Emergency Medicine, and
2Departments of Pediatrics and Emergency Medicine, and
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Abstract

Background and Objective: Low serum 25-hydroxyvitamin D (25[OH]D) levels have been associated with increased susceptibility to and severity of respiratory viral infections. Hypovitaminosis D may be a modifiable risk factor in the severity of viral respiratory illnesses. The hypothesis for this study was that children hospitalized for respiratory illnesses would have lower serum 25(OH)D levels than controls and that 25(OH)D levels would be associated with illness severity among cases.

Methods: A case–control study of a sample of patients aged 6 months through 12 years hospitalized from January to May 2010 at an urban pediatric referral hospital was performed. Cases were children hospitalized for acute respiratory illnesses, and controls were children hospitalized for nonrespiratory illnesses. Illness severity among cases was assessed according to hospital length of stay, ICU admission, peripheral oxygen saturation, and pediatric risk of admission II score. Associations between serum 25(OH)D levels and dependent variables were tested for by using binary logistic and multivariable linear regression while controlling for admission diagnosis, age, gender, and race/ethnicity.

Results: The majority of cases (n = 38) and controls (n = 83) were African American (65.8% and 59.0%, respectively). Of the entire cohort (N = 121), 64.8% had vitamin D insufficiency (25[OH]D level ≤30 ng/mL) and 31.1% had vitamin D deficiency (25[OH]D level ≤20 ng/mL). Mean ± SD 25(OH)D levels did not differ between cases and controls (26.8 ± 11.5 vs 26.1 ± 10.6 ng/mL, respectively; P = .73).

Conclusions: Hypovitaminosis D was common among cases and controls, but it was not significantly associated with the presence or severity of respiratory illnesses.

  • asthma
  • respiratory illness
  • vitamin D
  • Abbreviations:
    1,25(OH)D
    1,25-dihydroxyvitamin D
    25(OH)D
    25-hydroxyvitamin D
    LC-MS
    liquid chromatography–tandem mass spectrometry
    LOS
    length of stay
    PRISA
    pediatric risk of admission
    • Copyright © 2013 by the American Academy of Pediatrics
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    Hospital Pediatrics: 3 (4)
    Hospital Pediatrics
    Vol. 3, Issue 4
    1 Oct 2013
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    Vitamin D in Pediatric Inpatients With Respiratory Illnesses
    Sabah Iqbal, Edward V. Mosenkis, Pankaj Jain, Andrew Wiles, Jennifer Lerner, Angela S. Benton, James M. Chamberlain, Robert J. Freishtat, Stephen J. Teach
    Hospital Pediatrics Oct 2013, 3 (4) 371-376; DOI: 10.1542/hpeds.2013-0001

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    Vitamin D in Pediatric Inpatients With Respiratory Illnesses
    Sabah Iqbal, Edward V. Mosenkis, Pankaj Jain, Andrew Wiles, Jennifer Lerner, Angela S. Benton, James M. Chamberlain, Robert J. Freishtat, Stephen J. Teach
    Hospital Pediatrics Oct 2013, 3 (4) 371-376; DOI: 10.1542/hpeds.2013-0001
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