Skip to main content

Advertising Disclaimer »

Main menu

  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors/Reviewers
    • Submit Manuscript
    • Author Guidelines
    • Reviewer Guidelines
    • Editorial Policies
  • Content
    • Current Issue
    • Online First
    • Archive
    • Topic/Program Collections
    • Blog
  • Subscribe
  • Alerts
  • Careers
  • Other Publications
    • American Academy of Pediatrics

User menu

  • Log in

Search

  • Advanced search
American Academy of Pediatrics

AAP Gateway

Advanced Search

AAP Logo

  • Log in
  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors/Reviewers
    • Submit Manuscript
    • Author Guidelines
    • Reviewer Guidelines
    • Editorial Policies
  • Content
    • Current Issue
    • Online First
    • Archive
    • Topic/Program Collections
    • Blog
  • Subscribe
  • Alerts
  • Careers
American Academy of Pediatrics
Research Articles

Comparative Effectiveness of Oral Versus Outpatient Parenteral Antibiotic Therapy for Empyema

Chris Stockmann, Krow Ampofo, Andrew T. Pavia, Carrie L. Byington, Xiaoming Sheng, Tom H. Greene, Ernest K. Korgenski and Adam L. Hersh
Hospital Pediatrics December 2015, 5 (12) 605-612; DOI: https://doi.org/10.1542/hpeds.2015-0100
Chris Stockmann
aDepartments of Pediatrics and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Krow Ampofo
aDepartments of Pediatrics and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrew T. Pavia
aDepartments of Pediatrics and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carrie L. Byington
aDepartments of Pediatrics and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xiaoming Sheng
aDepartments of Pediatrics and
bPopulation Health Sciences, University of Utah School of Medicine, Salt Lake City, Utah; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tom H. Greene
aDepartments of Pediatrics and
bPopulation Health Sciences, University of Utah School of Medicine, Salt Lake City, Utah; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ernest K. Korgenski
cPediatric Clinical Program, Intermountain Healthcare, Salt Lake City, Utah
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Adam L. Hersh
aDepartments of Pediatrics and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Comments
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Download PDF

Abstract

BACKGROUND: Treatment of pediatric parapneumonic empyema (PPE) requires several weeks of antibiotic therapy that is typically completed in the outpatient setting. The route of outpatient therapy can be oral or intravenous (outpatient parenteral antibiotic therapy [OPAT]). No studies have compared outcomes between oral therapy and OPAT for PPE.

METHODS: We identified children <18 years hospitalized from 2005 to 2014 at Primary Children’s Hospital with PPE and discharged with oral therapy or OPAT. The primary outcome was the percentage of children who experienced all-cause complications after discharge. Complications included those that were related to pneumonia (including treatment failure, defined as readmission with reaccumulation of pleural fluid or abscess requiring drainage) or antibiotic therapy (eg, allergy, line clot) resulting in either a hospital readmission or emergency department/urgent care visit. All-cause complications were compared between oral therapy and OPAT by using propensity score–weighted logistic regression.

RESULTS: A total of 391 children were hospitalized with PPE; 337 (86%) were discharged with OPAT; 35 (9%) children experienced an all-cause complication, including 5 with oral (9.3%) and 30 (8.9%) with OPAT. Pneumonia and treatment-related complications were comparable (P = .25 and .78, respectively). Two patients treated with OPAT (1%) experienced treatment failure. After adjustment using propensity score weighting, the frequency of complications was similar between groups (adjusted odds ratio 0.97, 95% confidence interval 0.23–4.65).

CONCLUSIONS: The frequency of complications was similar with oral therapy and OPAT for children with PPE. Oral antibiotics may be considered safe and effective for children with PPE who will be discharged to complete therapy in the outpatient setting.

  • Copyright © 2015 by the American Academy of Pediatrics
View Full Text

Individual Login

Log in
You will be redirected to aap.org to login or to create your account.

Institutional Login

via Institution

You may be able to gain access using your login credentials for your institution. Contact your librarian or administrator if you do not have a username and password.

Log in through your institution

If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.

Pay Per Article - You may access this article (from the computer you are currently using) for 2 days for US$25.00

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

Offer Reprints

PreviousNext
Back to top

Advertising Disclaimer »

In this issue

Hospital Pediatrics: 5 (12)
Hospital Pediatrics
Vol. 5, Issue 12
1 Dec 2015
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
View this article with LENS
PreviousNext
Email Article

Thank you for your interest in spreading the word on American Academy of Pediatrics.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Comparative Effectiveness of Oral Versus Outpatient Parenteral Antibiotic Therapy for Empyema
(Your Name) has sent you a message from American Academy of Pediatrics
(Your Name) thought you would like to see the American Academy of Pediatrics web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Request Permissions
Article Alerts
Log in
You will be redirected to aap.org to login or to create your account.
Or Sign In to Email Alerts with your Email Address
Citation Tools
Comparative Effectiveness of Oral Versus Outpatient Parenteral Antibiotic Therapy for Empyema
Chris Stockmann, Krow Ampofo, Andrew T. Pavia, Carrie L. Byington, Xiaoming Sheng, Tom H. Greene, Ernest K. Korgenski, Adam L. Hersh
Hospital Pediatrics Dec 2015, 5 (12) 605-612; DOI: 10.1542/hpeds.2015-0100

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Comparative Effectiveness of Oral Versus Outpatient Parenteral Antibiotic Therapy for Empyema
Chris Stockmann, Krow Ampofo, Andrew T. Pavia, Carrie L. Byington, Xiaoming Sheng, Tom H. Greene, Ernest K. Korgenski, Adam L. Hersh
Hospital Pediatrics Dec 2015, 5 (12) 605-612; DOI: 10.1542/hpeds.2015-0100
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Print
Download PDF
Insight Alerts
  • Table of Contents

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Comments

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Economic Burden of Home Antimicrobial Therapy: OPAT Versus Oral Therapy
  • Management of Pediatric Community-acquired Bacterial Pneumonia
  • Oral antibiotics are as effective as intravenous antibiotics for postdischarge treatment of complicated pneumonia in children
  • Intravenous Versus Oral Antibiotics for Postdischarge Treatment of Complicated Pneumonia
  • Something Doesnt Smell Right: When a Patient With Empyema Isnt Responding to Guideline-Based Management
  • Toward Optimal Outpatient Therapy for Pediatric Parapneumonic Empyema
  • Google Scholar

More in this TOC Section

  • Enteral Nutrition Improves Vital Signs in Children With Bronchiolitis on Noninvasive Ventilation
  • High-Flow Nasal Cannula in Bronchiolitis at a Pediatric Emergency Department: Trends and Outcomes
  • Intent, Substance, and Care: Characteristics of Adolescent Ingestion Hospitalizations
Show more Research Articles

Similar Articles

Subjects

  • Infectious Disease
    • Infectious Disease
  • Hospital Medicine
    • Hospital Medicine
    • Continuity of Care Transition & Discharge Planning
  • Journal Info
  • Editorial Board
  • Editorial Policies
  • Overview
  • Licensing Information
  • Authors/Reviewers
  • Author Guidelines
  • Reviewer Guidelines
  • Submit My Manuscript
  • Librarians
  • Institutional Subscriptions
  • Usage Stats
  • Support
  • Subscribe
  • Contact Us
  • Resources
  • Media Kit
  • About
  • International Access
  • Terms of Use
  • Privacy Statement
  • FAQ
  • RSS Feeds
  • shopAAP
  • AAP.org
  • Follow American Academy of Pediatrics on Instagram
  • Visit American Academy of Pediatrics on Facebook
  • Follow American Academy of Pediatrics on Twitter
  • Follow American Academy of Pediatrics on Youtube
American Academy of Pediatrics

© 2021 American Academy of Pediatrics