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American Academy of Pediatrics
Research Articles

Empiric Antibiotic Use and Susceptibility in Infants With Bacterial Infections: A Multicenter Retrospective Cohort Study

Elana A. Feldman, Russell J. McCulloh, Angela L. Myers, Paul L. Aronson, Mark I. Neuman, Miranda C. Bradford, Elizabeth R. Alpern, Frances Balamuth, Mercedes M. Blackstone, Whitney L. Browning, Katie Hayes, Rosalynne Korman, Rianna C. Leazer, Lise E. Nigrovic, Richard Marble, Emily Roben, Derek J. Williams and Joel S. Tieder
Hospital Pediatrics August 2017, 7 (8) 427-435; DOI: https://doi.org/10.1542/hpeds.2016-0162
Elana A. Feldman
aUniversity of Washington School of Medicine, Seattle, Washington;
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Russell J. McCulloh
bDivision of Infectious Diseases, Department of Pediatrics, Children’s Mercy, University of Missouri–Kansas City School of Medicine, Kansas City, Missouri;
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Angela L. Myers
bDivision of Infectious Diseases, Department of Pediatrics, Children’s Mercy, University of Missouri–Kansas City School of Medicine, Kansas City, Missouri;
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Paul L. Aronson
cSection of Pediatric Emergency Medicine, Departments of Pediatrics and Emergency Medicine, Yale School of Medicine, New Haven, Connecticut;
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Mark I. Neuman
dDivision of Emergency Medicine, Department of Pediatrics, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;
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Miranda C. Bradford
eCenter for Clinical and Translational Research, Seattle Children’s Hospital, Seattle, Washington;
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Elizabeth R. Alpern
fDivision of Emergency Medicine, Ann and Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois;
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Frances Balamuth
gCenter for Pediatric Clinical Effectiveness and Division of Emergency Medicine, Department of Pediatrics, The Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania;
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Mercedes M. Blackstone
gCenter for Pediatric Clinical Effectiveness and Division of Emergency Medicine, Department of Pediatrics, The Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania;
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Whitney L. Browning
hDivision of Hospital Medicine, Department of Pediatrics, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Vanderbilt University School of Medicine, Nashville, Tennessee; and
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Katie Hayes
gCenter for Pediatric Clinical Effectiveness and Division of Emergency Medicine, Department of Pediatrics, The Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania;
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Rosalynne Korman
hDivision of Hospital Medicine, Department of Pediatrics, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Vanderbilt University School of Medicine, Nashville, Tennessee; and
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Rianna C. Leazer
iDivision of Hospital Medicine, Children’s Hospital of The King’s Daughters, Norfolk, Virginia
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Lise E. Nigrovic
dDivision of Emergency Medicine, Department of Pediatrics, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;
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Richard Marble
fDivision of Emergency Medicine, Ann and Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois;
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Emily Roben
fDivision of Emergency Medicine, Ann and Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois;
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Derek J. Williams
hDivision of Hospital Medicine, Department of Pediatrics, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Vanderbilt University School of Medicine, Nashville, Tennessee; and
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Joel S. Tieder
eCenter for Clinical and Translational Research, Seattle Children’s Hospital, Seattle, Washington;
jDivision of Hospital Medicine
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Article Information

vol. 7 no. 8 427-435
DOI 
https://doi.org/10.1542/hpeds.2016-0162
PubMed 
28729240

Published By 
American Academy of Pediatrics
Print ISSN 
2154-1663
Online ISSN 
2154-1671
History 
  • Published online August 1, 2017.

Article Versions

  • previous version (July 20, 2017 - 00:08).
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Copyright & Usage 
Copyright © 2017 by the American Academy of Pediatrics

Author Information

  1. Elana A. Feldman, MDa,
  2. Russell J. McCulloh, MDb,
  3. Angela L. Myers, MD, MPHb,
  4. Paul L. Aronson, MDc,
  5. Mark I. Neuman, MD, MPHd,
  6. Miranda C. Bradford, MSe,
  7. Elizabeth R. Alpern, MDf,
  8. Frances Balamuth, MD, PhDg,
  9. Mercedes M. Blackstone, MDg,
  10. Whitney L. Browning, MDh,
  11. Katie Hayes, BSg,
  12. Rosalynne Korman, MDh,
  13. Rianna C. Leazer, MDi,
  14. Lise E. Nigrovic, MD, MPHd,
  15. Richard Marble, MDf,
  16. Emily Roben, MDf,
  17. Derek J. Williams, MD, MPHh and
  18. Joel S. Tieder, MD, MPHe,j
  1. aUniversity of Washington School of Medicine, Seattle, Washington;
  2. bDivision of Infectious Diseases, Department of Pediatrics, Children’s Mercy, University of Missouri–Kansas City School of Medicine, Kansas City, Missouri;
  3. cSection of Pediatric Emergency Medicine, Departments of Pediatrics and Emergency Medicine, Yale School of Medicine, New Haven, Connecticut;
  4. dDivision of Emergency Medicine, Department of Pediatrics, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;
  5. eCenter for Clinical and Translational Research, Seattle Children’s Hospital, Seattle, Washington;
  6. fDivision of Emergency Medicine, Ann and Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois;
  7. gCenter for Pediatric Clinical Effectiveness and Division of Emergency Medicine, Department of Pediatrics, The Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania;
  8. hDivision of Hospital Medicine, Department of Pediatrics, Monroe Carell Jr. Children’s Hospital at Vanderbilt, Vanderbilt University School of Medicine, Nashville, Tennessee; and
  9. iDivision of Hospital Medicine, Children’s Hospital of The King’s Daughters, Norfolk, Virginia
  10. jDivision of Hospital Medicine
  1. Address correspondence to Elana A. Feldman, MD, C/O Joel Tieder, MD Seattle Children’s Hospital, FA.2.115, Hospital Medicine, 4800 Sand Point Way NE, Seattle, WA 98105. E-mail: elana.a.feldman{at}gmail.com
  1. Dr Feldman conceptualized and designed the study and data collection instrument, acquired data for her site, interpreted the data, and drafted the initial manuscript; Dr McCulloh made a substantial contribution to the conception and design of the study and data collection instrument, contributed expertise in the field of infectious disease, and revised the manuscript for intellectual content; Dr Myers made a substantial contribution to the conception and design of the study, contributed expertise in the field of infectious disease, and revised the manuscript for intellectual content; Dr Aronson made a substantial contribution to the conception and design of the study including cohort selection, acquired data for his site, and revised the manuscript for intellectual content; Dr Neuman made a substantial contribution to the conception and design of the study, revised the manuscript for intellectual content, and acquired data for his site; Ms Bradford contributed the statistical analysis of data and drafted the figures and tables; Drs Alpern, Balamuth, Blackstone, Browning, Marble, Roben, and Williams made a substantial contribution to the conception and design of the study and revised the manuscript for intellectual content; Ms Hayes and Drs Korman, Leazer, and Nigrovic made a substantial contribution to the conception and design of the study, acquired data for their sites, and revised the manuscript for intellectual content; Dr Tieder made a substantial contribution to the conception and design of the study and data collection instrument and revised the manuscript for intellectual content; and all authors approved the final manuscript as submitted.

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Empiric Antibiotic Use and Susceptibility in Infants With Bacterial Infections: A Multicenter Retrospective Cohort Study
Elana A. Feldman, Russell J. McCulloh, Angela L. Myers, Paul L. Aronson, Mark I. Neuman, Miranda C. Bradford, Elizabeth R. Alpern, Frances Balamuth, Mercedes M. Blackstone, Whitney L. Browning, Katie Hayes, Rosalynne Korman, Rianna C. Leazer, Lise E. Nigrovic, Richard Marble, Emily Roben, Derek J. Williams, Joel S. Tieder
Hospital Pediatrics Aug 2017, 7 (8) 427-435; DOI: 10.1542/hpeds.2016-0162

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Empiric Antibiotic Use and Susceptibility in Infants With Bacterial Infections: A Multicenter Retrospective Cohort Study
Elana A. Feldman, Russell J. McCulloh, Angela L. Myers, Paul L. Aronson, Mark I. Neuman, Miranda C. Bradford, Elizabeth R. Alpern, Frances Balamuth, Mercedes M. Blackstone, Whitney L. Browning, Katie Hayes, Rosalynne Korman, Rianna C. Leazer, Lise E. Nigrovic, Richard Marble, Emily Roben, Derek J. Williams, Joel S. Tieder
Hospital Pediatrics Aug 2017, 7 (8) 427-435; DOI: 10.1542/hpeds.2016-0162
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