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American Academy of Pediatrics
Research Articles

Retrospective Application of BRUE Criteria to Patients Presenting With ALTE

Jessica S. Meyer, Eliza G. Stensland, Jennifer Murzycki, Cathleen Renzi Gulen, Alexandra Evindar and Megan Z. Cardoso
Hospital Pediatrics December 2018, 8 (12) 740-745; DOI: https://doi.org/10.1542/hpeds.2018-0044
Jessica S. Meyer
aFloating Hospital for Children at Tufts Medical Center, Boston, Massachusetts;
bSchool of Medicine, Tufts University, Boston, Massachusetts; and
cLowell General Hospital, Lowell, Massachusetts
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Eliza G. Stensland
aFloating Hospital for Children at Tufts Medical Center, Boston, Massachusetts;
bSchool of Medicine, Tufts University, Boston, Massachusetts; and
cLowell General Hospital, Lowell, Massachusetts
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Jennifer Murzycki
aFloating Hospital for Children at Tufts Medical Center, Boston, Massachusetts;
bSchool of Medicine, Tufts University, Boston, Massachusetts; and
cLowell General Hospital, Lowell, Massachusetts
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Cathleen Renzi Gulen
aFloating Hospital for Children at Tufts Medical Center, Boston, Massachusetts;
bSchool of Medicine, Tufts University, Boston, Massachusetts; and
cLowell General Hospital, Lowell, Massachusetts
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Alexandra Evindar
cLowell General Hospital, Lowell, Massachusetts
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Megan Z. Cardoso
aFloating Hospital for Children at Tufts Medical Center, Boston, Massachusetts;
bSchool of Medicine, Tufts University, Boston, Massachusetts; and
cLowell General Hospital, Lowell, Massachusetts
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    TABLE 1

    ICD-9 and ICD-10 Codes Searched

    DiagnosisICD-9/ICD-10 Codes
    ALTE799.82/R69/R68.13
    Altered mental status780.97/R41.82
    Apnea786.03/R06.81
    Breath-holding spell786.9/R06.89
    Choking933.1/T17.308A
    Gastroesophageal reflux530.81/K21.9
    Hypotonia781.3/R29.898
    Lethargy780.79/R53.83
    Other convulsions780.39/R53.9
    Pallor782.61/R23.1
    Seizure780.39/R56.9
    Sleep apnea780.57/G47.30
    Syncope780.2/R55
    Unresponsiveness780.09/R41.89
    • View popup
    TABLE 2

    Patient Characteristics, Outcomes, and Missing Data in Patients With ALTE Versus Patients With BRUE

    Patients Diagnosed With ALTEPatients With ALTE Who Meet BRUE Criteria
    Patient characteristics, n8720
     Median age, d3856
     Female sex, n (%)55 (63.2)13 (65)
     Initial presentation to ED, n (%)69 (79.3)17 (85)
     Direct admission to pediatric floor, n (%)18 (20.7)3 (15)
    Disposition of ED patients, n (%)6917
     Admit to pediatric floor45 (65.2)9 (52.9)
     Discharge from the hospital17 (24.6)7 (35)
     Transfer to tertiary-care center6 (8.7)0 (0)
     Leave against medical advice1 (1.4)1 (5.9)
    Disposition of floor patients, n (%)6312
     Discharge from the hospital60 (95.2)12 (100)
     Transfer to tertiary-care center,3 (4.8)0 (0)
    Additional patient outcomes, n (%)8720
     Recurrent events in the hospital (ED or floor)17 (19.5)2 (10)
     Re-presentation within 30 d with similar complaint6 (6.9)1 (5)
    Data not documented in chart, n (%)8720
     Cyanosis6 (6.9)2 (10)
     Pallor44 (50.6)9 (45)
     Irregular breathing8 (9.2)1 (5)
     Tone change39 (44.8)7 (35)
     Altered level of consciousness42 (48.2)8 (40)
     Event >1 min15 (17.2)2 (10)
     Born <32 wk or corrected gestational age <45 wk6 (6.9)1 (5)
     Cluster of events2 (2.3)0 (0)
    • View popup
    TABLE 3

    Laboratory and Radiographic Testing Performed on All Patients With ALTE Versus Patients With BRUE

    TestPatients With ALTE, n = 87, n (%)Patients With BRUE, n = 20), n (%)
    Any laboratory or radiologic testing43 (49.4)8 (40)
    Complete blood count23 (26.4)4 (20)
    Blood culture11 (12.6)0 (0)
    Cerebrospinal fluid analysis4 (4.6)0 (0)
    Basic metabolic panel20 (23.0)5 (25)
    Pertussis testing1 (1.1)0 (0)
    Rapid RSV13 (14.9)1 (5)
    Rapid influenza6 (6.9)1 (5)
    Respiratory viral panel1 (1.1)1 (5)
    Urinalysis10 (11.5)2 (10)
    Blood glucose21 (24.1)6 (30)
    Lactate1 (1.1)0 (0)
    Chest radiograph12 (13.8)2 (10)
    Head computed tomography5 (5.7)1 (5)
    Head ultrasound1 (1.1)0 (0)
    pH probe1 (1.1)0 (0)
    Abdominal ultrasound1 (1.1)0 (0)
    Electrocardiogram13 (14.9)2 (10)
    • RSV, respiratory syncytial virus.

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Hospital Pediatrics: 8 (12)
Hospital Pediatrics
Vol. 8, Issue 12
1 Dec 2018
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Retrospective Application of BRUE Criteria to Patients Presenting With ALTE
Jessica S. Meyer, Eliza G. Stensland, Jennifer Murzycki, Cathleen Renzi Gulen, Alexandra Evindar, Megan Z. Cardoso
Hospital Pediatrics Dec 2018, 8 (12) 740-745; DOI: 10.1542/hpeds.2018-0044

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Retrospective Application of BRUE Criteria to Patients Presenting With ALTE
Jessica S. Meyer, Eliza G. Stensland, Jennifer Murzycki, Cathleen Renzi Gulen, Alexandra Evindar, Megan Z. Cardoso
Hospital Pediatrics Dec 2018, 8 (12) 740-745; DOI: 10.1542/hpeds.2018-0044
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