TABLE 4

Oral Vitamin K Regimens and VKDB Cases

Study, CountryMethodsOral Vitamin KNo. Live BirthsIncidence of VKDB
Laubscher et al,62 SwitzerlandSurvey of cases recalled by pediatricians3 doses × 2 mg: 4 h of life, day 4, week 4458 184Overall incidence: 1.09 in 100 000 (95% CI 0.4–2.6); late VKDB incidence: 0.87 in 100 000 (95% CI 0.24–2.24)
Hansen et al,63 DenmarkSurvey of parents and survey of cases recalled by pediatriciansMultiple doses: 2 mg at birth, 1 mg weekly until 3 mo of age507 850Incidence: 0–0.9 per 100 000
von Kries et al,64 GermanySurvey of cases recalled by pediatricians3 doses × 2 mg: birth, week 1, and week 43 138 695Incidence: late VKDB 0.44 in 100 000 (95% CI 0.19–0.87)
Wariyar et al,65 United KingdomChart review, survey of parents, and survey of cases recalled by pediatricians4 doses × 1 mg: birth, (breastfed infants) week 2, week 4, and week 6182 000Incidence: late VKDB 2.2 in 100 000
Strehle et al,66 United KingdomSurvey of midwivesMultiple doses: 1 mg given at birth, 50 µg for 3 mo (breastfed infant)Outcomes were acceptability of regimen by parents and midwives; investigators did not track cases of VKDB
Schubiger et al,9 SwitzerlandMonthly survey of pediatric hospitals on VKDB cases2 doses × 2 mg: day 1 and day 4247 000Incidence: late VKDB 2.8 in 100 000 live births
Von Kries et al,10 GermanyMonthly survey of pediatric hospitals on VKDB cases3 doses × 2 mg: birth, days 4–10, weeks 4–63 200 000Incidence: late VKDB ranged from 0.44 to 0.72 in 100 000 live births
  • CI, confidence interval.