TABLE 3

Laboratory Testing and Empirical Acyclovir for All Infants Evaluated for Serious Infection by Age at Presentation and HSV Status

Laboratory TestingInfants With HSV (n = 19), n (%)Infants Without HSV, n (%)
0–28 d (n = 915)29–60 d (n = 699)
Individual HSV PCR tests
 CSF15 (79)393 (43)109 (16)
 Serum14 (74)45 (4.9)10 (1.4)
 Surface6 (32)37 (4.0)7 (1.0)
 Lesion or vesiclea7 (37)24 (2.6)6 (0.9)
ALT or AST tests17 (89)112 (12)46 (6.6)
Complete evaluationb4 (22)14 (1.5)
  • ALT, alanine aminotransferase; AST, aspartate aminotransferase; —, not indicated.

  • a A lesion or vesicle PCR was only obtained when the patient had a suspicious skin finding.

  • b Complete evaluation was defined as HSV PCR testing from the CSF, serum, surface, and lesion (if present) as well as ALT or AST testing.