TABLE 1

Characteristics of Infants Evaluated for SBI

CharacteristicsInfants With HSV Infection (n = 19)Infants Without HSV infection (n = 1614)
Average age at presentation, mean ± SD, d11.3 ± 6.626.4 ± 14.7*
 ≤28 d (n = 19 with HSV)11.3 ± 6.615.6 ± 7.7
 29–60 d (n = 0 with HSV)40.6 ± 8.4
Male sex, n (%)11 (58)905 (56)
Gestational age <34 wk, n (%)051 (3)
HSV exposure, n (%)
 Maternal HSV symptoms6 (32)13 (0.8)*
 Other known HSV contacts1 (5.3)13 (0.8)
Symptoms and PE findings at presentation, n (%)
 Fever ≥38°C7 (37)1152 (71)*
 Hypothermia <36°Ca4 (22)43 (2.7)*
 Ill appearance or poor perfusion10 (53)83 (5.1)*
 Respiratory symptoms5 (26)353 (22)
  Difficulty breathing5 (26)171 (11)*
  Apneaa2 (11)55 (3.4)
 GI symptoms13 (68)735 (46)
  Poor feeding12 (63)591 (37)*
  Vomiting1 (5.3)192 (12)
 Neurologic symptoms10 (53)361 (22)*
  Seizure3 (16)56 (3.5)*
  Altered mental status6 (32)54 (3.3)*
  Abnormal neurologic examination4 (22)7 (0.4)*
 Skin and soft tissue symptoms6 (32)115 (7.1)*
  Vesicular or petechial rash6 (32)31 (1.9)*
  Poorly healing scalp electrode site1 (5.3)3 (0.2)*
 HEENT symptoms1 (5.3)45 (2.8)
 Genitourinary symptoms14 (0.9)
 Hematologic symptoms2 (11)8 (0.5)*
  Excessive bleeding2 (11)*
  • GI, gastrointestinal; HEENT, head, neck, eyes, ears, nose, and throat; PE, physical examination; —, not applicable.

  • a In infants >34 wk gestation.

  • * P < .05. Two-sample t test was used for age at presentation. Fisher’s exact test was used for all other variables.