TABLE 2

Laboratory and Microbiologic Indices Among Pediatric and Adolescent Patients With SARS-CoV-2 and Comparison Between Those Admitted to Acute or Critical Care Units

Laboratory IndicesaAvailable Data, nAll (n = 82)Acute Care (n = 59)Critical Care (n = 23)P
Hemoglobin, <10 mg/dL7811/78 (14)7/56 (13)4/22 (18).49
Platelets, <150 × 103/μL7611/76 (15)6/54 (11)5/22 (23).19
White blood cells count
 <5 × 103/μL7817/78 (22)14/56 (25)3/22 (14).37
 >11 × 103/μLb65b21/65 (32)12/45 (27)9/20 (45).15
 >30 × 103/μL for newborns <28 d of life130/130/110/2
Absolute lymphocyte count, <1500 cells/μL7728/77 (36)18/56 (32)10/21 (48).21
Absolute neutrophils count, <1500 cells/μL7810/78 (13)9/56 (16)1/22 (5).27
CRP, >10 mg/dL5436/54 (67)18/34 (53)18/20 (90).005
Procalcitonin, ≥0.5 ng/mL3512/35 (34)5/19 (26)7/16 (44).41
IL-6, ≥5 pg/mL2920/29 (69)10/18 (56)10/11 (91).04
D-dimer, ≥250 ng/mL2315/23 (65)9/14 (64)6/9 (67).91
Ferritin, ≥250 ng/mL218/21 (38)4/11 (36)4/10 (40).99
Lactate dehydrogenase, ≥250 IU/L3328/33 (85)17/20 (85)11/13 (85).97
Creatinine, elevated level for agec6914/69 (20)5/48 (10)9/21 (43).002
eGFRd, <90 mL/min/1.73 m24214/42 (33)5/26 (19)9/16 (56).01
Troponins, >0.5 ng/dL272/27 (7)0/13 (0)2/14 (14).48
Aspartate aminotransferase, >40 U/L6129/61 (48)16/41 (39)13/20 (65).06
Alanine aminotransferase, >40 U/L6213/62 (21)4/42 (10)9/20 (45).002
Microbiologic indices
 Blood culture positive582/58 (3)0/37 (0)2/21 (10).13
 Urine culture positive342/34 (6)1/21 (5)1/13 (8).99
 Cerebrospinal fluid culture positive190/190/170/2
 Respiratory viral panel positivee (except SARS-CoV-2)473/47 (6)1/32 (3)2/15 (13).24
 Coinfection (bacterial or viral or fungal)8212/82 (15)5/59 (8)7/23 (30).01
  • eGFR, estimated glomerular filtration rate; —, not applicable.

  • a All values expressed as n/number of patients with available data for a variable in that category (%).

  • b Excluding infants <28 d of life.

  • c Normal values range used for “creatinine for age19” in mg/dL: newborn: 0.3–1.0, infant: 0.2–0.4, 1 to 9 y: 0.3–0.7, 10 to 17 y: 0.5–1.0, 18 to 21 y: 0.9–1.3 (male), 0.6–1.1 (female).

  • d Denominator for eGFR includes patients ≥2 y age, eGFR calculated using “bedside Schwartz equation21” for patients aged 2 to 17 y and “Chronic Kidney Disease Epidemiology Collaboration creatinine equation20” for patients aged 18–21 y.

  • e BioFire FilmArray respiratory panel (bioMérieux).