TABLE 3

Results of ITS Analysis

Outcome, OR (95% CI)	Period
Outcome, OR (95% CI)	Pre-2016	2016–2017	2016–2017^a	Post-2017	Post-2017^a
ED HFNC initiation	Reference	1.30 (0.91–1.88)	1.67 (1.12–2.49)^*	1.97 (1.14–3.43)^*	2.55 (1.39–4.68)^*
Admission	Reference	0.95 (0.79–1.14)	1.16 (0.95–1.43)	1.06 (0.77–1.45)	1.18 (0.82–1.71)
PICU admission	Reference	1.33 (0.95–1.86)	1.53 (0.95–3.20)	1.51 (0.84–2.69)	1.74 (0.95–3.20)
Transfer to PICU	Reference	1.46 (0.76–2.80)	1.53 (0.80–2.94)	2.28 (0.80–6.49)	2.32 (0.81–6.66)
Intubation	Reference	1.15 (0.57–2.33)	1.37 (0.65–2.88)	3.75 (1.08–12.95)^*	4.93 (1.36–17.85)^*

↵a Adjusted for age, ESI level, triage Spo₂, and lowest ED Spo₂.
↵* P < .05.