TABLE 1

Number of Troughs Within Target Range (10–20 μg/mL)

Dose (mg/kg per day)2–23 mo (%)2–5 y (%)6–12 y (%)13–17 y (%)Total (%)
<451/10 (10)1/11 (9.1)3/12 (25)4/12 (33.3)9/45 (20)
501/4 (25)0/9 (0)1/4 (25)0/2 (0)2/19 (10.5)
602/10 (20)4/25 (16)8/21 (38.1)6/7 (85.7)20/63 (31.7)
701/3 (33.3)5/11 (45.5)2/7 (28.6)8/21 (38.1)
>752/2 (100)3/4 (75)2/4 (50)0/1 (0)7/11 (63.6)
Total7/29 (24.1)13/60 (21.7)16/48 (33.3)10/22 (45.5)46/159 (28.9)