TABLE 3

Age-Related Differences in Dose and Trough Concentrations

Category2–23 mo (n = 29)2–5 y (n = 60)6–12 y (n = 48)13–17 y (n = 22)
Average trough concentration μg/mL10.3 ± 13.87.3 ± 3.09.6 ± 5.012.8 ± 7.2
No. troughs within target range of 10–20 μg/mL, (%)7 (24.1)13 (21.7)16 (33.3)10 (45.5)
Average daily dose (mg/kg per day)57.3 ± 10.357.2 ± 11.857.1 ± 13.747.8 ± 11.5
Average daily dose when trough <10 μg/mL52.9 ± 9.654.6 ± 10.555.9 ± 13.544.0 ± 13.6
Average daily dose when trough 10–20 μg/mL69.7 ± 14.766.5 ± 12.059.4 ± 14.251.3 ± 9.6