TABLE 1

Characteristics of Hospitalized Patients Treated With an AED and Those With a pDDI

pDDIs
Treated With an AED (N = 434 794)Severe (n = 117 880)Nonsevere (n = 63 500)None (n = 253 414)
Age, median (IQR), y8.3 (2.7, 14.3)6.5 (0.8, 14.1)11.0 (5.0, 15.5)8.2 (3.2, 18.3)
Male gender, %53.452.256.553.4
Number of hospital days, median (IQR)3 (2, 8)6 (3, 16)4 (2, 9)3 (1, 9)
Number of AEDs per hospitalization, median (IQR)1 (1, 2)1 (1, 2)1 (1, 2)1 (1, 2)
Number of non-AEDs per hospitalization, median (IQR)12 (6, 21)20 (12, 31)14 (8, 22)8 (4,16)
ICU stay, %27.645.527.719.2
Operating room procedure, %26.144.527.017.2
Number of consulting services, median (IQR)2 (0, 2)2 (0, 2)2 (0, 2)2 (0, 2)
Diagnosis count, median (IQR)6 (3, 11)8 (5, 14)7 (4, 11)5 (3, 9)
Most common specialty of attending physician (top 3), %Pediatrics (22.2), Neurology (19.4), Hematology-Oncology (8.8)Pediatrics (21.8), Neurology (10.0), Surgery-Neurologic (9.5)Pediatrics (21.4), Neurology (14.1), Hematology-Oncology (12.0)Neurology (25.2), Pediatrics (22.6), Hematology-Oncology (9.7)
Most common APR-DRG diagnosis (top 3), %Seizure (25.4), craniotomy for trauma (3.6), chemotherapy (3.1)Seizure (12.3), craniotomy for trauma (5.5), migraine/other headache (4.7)Seizure (19.1), bipolar (4.3), craniotomy for trauma (4.0)Seizure (33.0), chemotherapy (4.2), craniotomy for trauma (2.7)
  • A Kruskal-Wallis or χ2 analysis was performed to compare patients with severe, nonsevere, and no potential drug-drug interactions. All results were significant (P < .001). The most common specialties and diagnoses were not compared statistically. APR-DRG, all patient refined-diagnosis–related group; IQR, interquartile range.