TABLE 1

CSF Parameters for Tuberculous and Fungal Meningitis

OrganismCSF WBC CountDifferentialGlucoseProteinCSF Testing
M tuberculosisIncreasedMononuclearDecreasedIncreasedAFB smear, PCR and AFB culture
C neoformansIncreased or normalMononuclearDecreasedIncreasedIndia ink, cryptococcal antigen, fungal culture
C immitusIncreased or normalEarly neutrophilic, lymphocytic, or eosinophilicDecreasedIncreasedComplement fixation serum antibody, fungal culture
H capsulatumIncreasedMononuclearDecreasedIncreasedHistoplasma antigen, fungal culture
B dermatitidisIncreasedEarly neutrophilic or lymphocyticDecreasedIncreasedFungal culture
  • Adapted from Zunt JR, Baldwin KJ. Chronic and subacute meningitis. Continuum (Minneap Minn). 2012;18(6):1290–1318. AFB, acid-fast bacilli; PCR, polymerase chain reaction.