TABLE 1

Clinical Characteristics of Patients Admitted With Sepsis and for Other Reasons

VariableIndex Nonsepsis Admissions (N = 555 183)Index Sepsis Admissions (N = 7634)
Demographic
 Age <1 y, non-neonate308 183 (55.5)739 (9.7)
 Age 1–5 y60 049 (10.8)1719 (22.5)
 Age 6–12 y66 922 (12.1)1910 (25.0)
 Age 13–18 y120 029 (21.6)3266 (42.8)
 Female292 457 (52.7)4064 (53.2)
 Public insurance289 773 (52.3)4351 (57.1)
Chronic diseasea
 Previously healthy375 340 (67.6)1564 (20.5)
 Any chronic disease179 843 (32.4)6070 (79.5)
 Neurologic or neuromuscular conditions83 135 (15.0)3015 (39.5)
 Cardiovascular conditions13 668 (2.5)1353 (17.7)
 Respiratory conditions57 690 (10.4)1980 (25.9)
 Renal and urologic conditions14 844 (2.7)1778 (23.3)
 Gastrointestinal and hepatologic conditions38 541 (6.9)2672 (35.0)
 Hematologic and immunologic conditions11 745 (2.1)791 (10.4)
 Metabolic conditions21 555 (3.9)1429 (18.7)
 Congenital and genetic conditions5436 (1.0)582 (7.6)
 Oncologic conditions4426 (0.8)202 (2.6)
 Technology dependence17 901 (3.2)2188 (28.7)
 Solid organ transplant2208 (0.4)213 (2.8)
Organ failure
 Need for mechanical ventilation2771 (0.5)1960 (25.7)
 Presence of shock1322 (0.2)1463 (19.2)
 Acute renal failure1451 (0.3)1080 (14.1)
 Neurologic failure2209 (0.4)587 (7.7)
 Hepatic failure140 (0.0)70 (0.9)
 Hematologic failure2065 (0.4)1341 (17.6)
Sepsis definitionb
 Explicit criteriaN/A3554 (46.6)
 Combined criteriaN/A5389 (70.6)
APRDRG illness severityc
 Mild and/or moderate severity523 030 (94.2)2489 (32.6)
 Major severity26 944 (4.9)2829 (37.1)
 Extreme severity5067 (0.9)2302 (30.2)
APRDRG risk of mortality
 Mild and/or moderate risk548 405 (98.8)4482 (58.7)
 Major risk3632 (0.7)1989 (26.1)
 Extreme risk3004 (0.5)1149 (15.1)
Hospital type
 Metropolitan teaching hospital100 494 (18.1)810 (10.6)
 Metropolitan nonteaching hospital403 458 (72.7)6510 (85.3)
 Nonmetropolitan hospital51 231 (9.2)314 (4.1)
Length of stay, median (IQR)2 (2–3)4 (2–9)
  • Cohort consists of children 18 y or younger and discharged alive and excluded neonates and those discharged against medical advice. All values expressed as frequency and percentage in parenthesis unless stated otherwise. APRDRG, all-patients refined diagnosis related group; IQR, interquartile range; N/A, not applicable.

  • a Because patients could have >1 chronic disease, percentages add to >100%.

  • b Because patients could meet either or both criteria, percentages add to >100%.

  • c APRDRG illness severity and mortality risk are proprietary and validated method of illness severity stratification by using administrative data.